A combined score of the plasma IFN-inducible chemokines, IFNγ-inducible protein 10 (IP-10/CXCL10), and IFN-inducible T cell α chemoattractant (I-TAC/CXCL11) highly correlated with the IFN gene expression signature in SSc patients in the Genetics versus Environment in Scleroderma Outcome Study (GENISOS) cohort study (102). Here, IFNA1 is linked to systemic sclerosis.