CDKN2A and liver angiosarcoma: Studies of liver angiosarcoma showed that p16INK4a was repressed by promoter methylation in 63% (12 out of 19) of tumor samples, whereas 5% (1 out of 19) exhibited homozygous deletion and 10% (2 of 19) exhibited loss of heterozygosity at the CDKN2A locus.