Activation of the oncogene K-ras through acquisition of specific point mutations is a common event in angiosarcoma, reportedly occurring in 29% of hepatic angiosarcomas (7 out of 24) and 60% of cardiac angiosarcomas (3 out of 5) (Przygodzki et al., 1997; Boivin-Angèle et al., 2000; Garcia et al., 2000). Here, KRAS is linked to angiosarcoma.