Notably, a recent study of genetic risk factors for hemangioma identified germline mutations in the genes encoding vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) and anthrax toxin receptor 1 (also known as tumor endothelial marker 8) that perturb VEGF signaling and contribute to disorganized angiogenesis (Jinnin et al., 2008). Here, ANTXR1 is linked to hemangioma.