PRDM14 overexpression is often correlated with genomic amplification (Forozan et al., 2000), and amplification and/or overexpression is significantly associated with high mitotic index, high histological grade and HER2 positivity of invasive breast cancer specimens (Moelans et al., 2010), as well as chemoresistance to cisplatin, etoposide, docetaxel and doxorubicin in cultured breast cancer cell lines (Nishikawa et al., 2007). The gene discussed is PRDM14; the disease is breast cancer.