We previously demonstrated that Prdm14 is a potent leukemia oncogene, which can cause B-, T- or mixed-lineage lymphoblastic leukemia when expressed in stem-cell-enriched bone marrow via retroviral transduction, albeit with incomplete penetrance and a long latency of 12–52 weeks (Dettman et al., 2011). Here, PRDM14 is linked to leukemia.