This finding is further validated by the experiments demonstrating that combined anti-TIM-3/PD-1 mAbs significantly prevented established tumor growth and even cured a fraction of mice in methylcholanthrene-induced fibrosarcomas and 6 different experimental mouse tumor models, supporting the potential of blocking TIM-3 in combination with other immune-regulatory mAbs for the treatment of cancer. Here, HAVCR2 is linked to fibrosarcoma.