Remarkably, combined anti-TIM-3/CD137 mAb increased the percentage and absolute number of tumor-infiltrating CD4+ and CD8+ T cells, while at the same time decreasing the immunosuppressive Treg and MDSC in peritoneal lavage, which gave rise to the significantly increased ratio of CD4+ and CD8+ T cells to immunosuppressive cells. This evidence concerns the gene TNFRSF9 and neoplasm.