In this study, using ID8 murine ovarian cancer model, we evaluated the therapeutic effect of single or combined anti-TIM-3 and anti-CD137 mAbs and found that combined anti-TIM-3/CD137 significantly suppressed the 10 days established peritoneal ID8 tumor growth, resulting in 60% of treated mice tumor free 90 days after tumor injection. The gene discussed is TNFRSF9; the disease is neoplasm.