Although genome-wide analysis of transcript isoform expression in the CEU HapMap population found no differences in the expression of GSDMB isoform ratios associated with the asthma haplotype in LCLs (lymphoblastoid cell lines) [30], the splicing of GSDMB has been shown to be associated with genotype of the related variant rs7216389 in brain and in peripheral blood mononucleated cells [31]. This evidence concerns the gene GSDMB and asthma.