INSR and hyperinsulinism: The high-fat diet reduces the expression of insulin receptors, inhibits the oxidation of fatty acids (FA) in skeletal muscles, diminishes the mRNA expression and intracellular protein content of GLUT4, and reduces the translocation of GLUT4 to the cell membrane [37,38], factors that may be responsible for the observed hyperglycemia and hyperinsulinemia in animals [39].