Altogether these data suggested that EGCG treatment suppresses in vivo TAM infiltration and inhibits polarization of TAM into tumor-promoting M2 macrophages, which was involved by decreased production of chemo-attractants, CSF-1 and CCL-2, from tumor cells, and down-regulation of M2 macrophage-associated cytokines, IL-6 and TGF-β and relative up-regulation of M1 macrophage-associated cytokine, TNF-α, in TMA from EGCG-treated tumor. Here, CCL2 is linked to neoplasm.