AKT1 and neoplasm: The vascular phenotype is consistent with a failure in remodeling such that normal patterning and vessel hierarchy were disturbed.48 Endothelial cells in growing tumors express activated Akt, which when modeled by transgenic endothelial expression of Myr-Akt were sufficient to recapitulate the abnormal structural and functional features of tumor blood vessels in nontumor tissues.