Notably, Akt activation is known to be associated with angiosarcoma of human, mice and chickens.29, 30, 45, 46 Furthermore, microvascular patterning is known to be controlled by fine-tuning the Akt-mediated signal transduction.47 Consistently, sustained signaling in response to the overexpression of Myr-Akt leads to embryonic lethality, edema and vascular malformations. The gene discussed is AKT1; the disease is vascular malformation.