Although pathophysiological roles of TCL1 are primarily investigated in immunological malignancies including human T-PLL,39, 40 AIDS-related lymphoma, and/or B-cell lymphoma,14, 41 knowledge is limited about pathophysiological roles of the TCL1 family proteins in non-lymphoid tissues or neoplastic diseases. The gene discussed is TCL1B; the disease is Lymphoma, AIDS-Related.