Relatively little is characterized about the pathophysiological roles of TCL1b, another major member of the TCL1 family protooncogene, in human neoplastic diseases.17, 18 In order to clarify the pathological functions of TCL1b underlying human neoplastic diseases, we first examined whether TCL1b can physically interact with Akt in mammalian cells. This evidence concerns the gene TCL1B and neoplasm.