Cardiac disease, brain metastases, renal function impairment (creatinine clearance <30 ml/min), and liver failure (total bilirubin>1.5 mg/dl, albumin>2.5 mg/dl, and elevated levels of transaminases) are also exclusion criteria[4], although some researchers have proved that the combination of oxaliplatin and capecitabine could also be tolerated in patients with hyperbilirubinemia and hepatic dysfunctions, respectively[16]. This evidence concerns the gene ALB and heart disorder.