Processing the 3' ends of histone pre-mRNAs within the histone locus body requires SLBP, the U7 snRNP, the NELF complex and the histone pre-mRNA cleavage complex (HCC), which is comprised of FLASH, LSm11, symplekin, cleavage stimulation factor 64 (CSTF64) and all subunits of the CPSF complex [277]. The gene discussed is SLBP; the disease is hepatocellular carcinoma.