To better understand the functional contribution of Ang-2 and VEGFR-3 to lymphangiogenesis and progress of OSCC, we used a double-labeling immunohistochemical staining of CD-34/D2-40 in blood vessels and lymphatic vessels of tumor specimens for determination of microvessel density and lymphatic vessel density among 112 cases. This evidence concerns the gene ANGPT2 and neoplasm.