ANGPT2 and neoplasm: Moreover, in these tumor specimens, we also performed immunohistochemical staining of VEGFR-3, a major regulator of lymphangiogenesis [4], to investigate the correlations between Ang-2 and VEGFR-3 expression and tumor lymphangiogenesis and progress and thereby reveal the role of Ang-2 and VEGFR-3 in lymphatic metastasis and clinical survival in OSCC patients.