Inhibition of lymphangiogenesis by targeting VEGFR-3 phosphorylation is considered to be a therapeutic strategy for inhibiting lymph node metastasis of diffuse-type gastric cancer [16].Previous studies by our group and others have suggested that Ang-2 might, in some cases, collaborate with VEGF to promote tumor angiogenesis [3], [17]. This evidence concerns the gene ANGPT2 and neoplasm.