We found that OSCC with high expression of both Ang-2 and VEGFR-3 had significantly higher LVD than OSCC with any other combination of Ang-2 and VEGFR-3 expression, whereas high expression of Ang-2 by itself was not associated with LVD or lymph node metastasis. Here, ANGPT2 is linked to metastatic malignant neoplasm in the lymph nodes.