Previous studies have already found certain kinds of polymorphisms in DNA repair proteins are associated with cancer, such as XRCC3 (Thr241Met), OGG1 (Ser326Cys) and XPD (Lys751Gln) with breast cancer, XRCC2 (R188H G>A), and XRCC3 (T241M C>T) with ovarian cancer, XPC C/A (i11) with sporadic colorectal cancer and so on. This evidence concerns the gene XPC and breast cancer.