LEP and Insulin resistance: Actually, the rate of obesity, hypertension and insulin resistance is higher among individuals born at low birth weight than those of normal weight [1] and the offspring of dams exposed to nutrient restriction or overfeeding during pregnancy and/or lactation exhibit several physiological disturbances linked to the metabolic syndrome including insulin resistance [2]–[4], reduced leptin sensitivity [5], hepatic steatosis [6], hypertension [7], [8] and hyperlipidemia [2], [9].