In previous studies in lung cancer cells, the invasion suppressor gene CRMP1 has been shown to inhibit cancer cell invasion through F-actin depolymerization and inhibition of filopodia formation, whereas the long isoform of CRMP1, promoted cell migration and filopodia formation by increasing the ratio of F-actin to G-actin [32], [39]. Here, CRMP1 is linked to cancer.