Compared with the wild-type genotype, patients with at least one polymorphic C allele at EZH2 rs6950683 (Table 3) or rs3757441 (Table 4) showed a 19.029-fold (95% CI: 1.733–208.866) or a 19.067-fold (95% CI: 1.747–208.155) increase in lymph-node metastasis, but a 0.421-fold (95% CI: 0.182–0.973) or a 0.481-fold (95% CI: 0.209–1.110) decrease in liver cirrhosis, respectively. Here, EZH2 is linked to metastatic malignant neoplasm in the lymph nodes.