Table 2 shows the genotype distributions and the association between HCC and EZH2 polymorphisms. In our recruited control group, the frequencies of EZH2 rs6950683 (χ2 value: 5.59), rs2302427 (χ2 value: 5.77), rs3757441 (χ2 value: 1.79), and rs41277434 (χ2 value: 0.32) were in Hardy-Weinberg equilibrium, respectively. The alleles with the highest distribution frequency at EZH2 rs6950683, rs2302427, rs3757441, and rs41277434 in both HCC patients and controls were homozygous T/T, homozygous C/C, homozygous T/T, and homozygous A/A, respectively. This evidence concerns the gene EZH2 and hepatocellular carcinoma.