Both MVAC (methotrexate, vinblastine, doxorubicin and cisplatin) and GC/Cis (gemcitabine and cisplatin) protocols used in the treatment of TCC patients with muscle invasive tumors contain drugs (cisplatin and doxorubicin) shown to be substrates for GSTP [5]. Here, GSTP1 is linked to tarsal-carpal coalition syndrome.