Cell populations capable of producing IFNγ in response to malaria include γδ Tcells, NK cells, CD1-restricted NKT cells [45], [46] and conventional CD4 and CD8 T cells [47], indicating a wide range of potential cellular interactions across the innate and adaptive immune systems capable of promoting phagocytosis and parasite killing in concert with opsonising antibodies. This evidence concerns the gene CD4 and malaria.