IFNG and Hyperglycemia: Known stimuli for IL-18 synthesis are hyperglycemia [10], [11], nuclear transcription factor -κB (NFκB) and interferon-gamma (IFNγ) [12], cathecholamines [13], angiotensin II [14] and inflammation in general, whereas IL-18 induces multiple effects downstream by stimulating maturation of T cells and inducing expression of chemokines, adhesion molecules and cytokines, including INFγ and matrix metalloproteinases (MMPs) in different cell types [12], including MMP-9 [15].