Of note, we find that LC3B is well response to chloroquine treatment in several cancer cell lines (A549, HCT116 and TPC-1) where LC3A and LC3C are lack of significant increase in LC3A-II or LC3C-II level (unpublished data), indicating LC3 family members may differentially involve in autophagy-related processes. This evidence concerns the gene MAP1LC3C and cancer.