HIF1A and Hepatic fibrosis: We firstly detected Hif-1α expression in liver tissues of Schistosomajaponicum infected mouse, which is regarded as a good model for infectious liver fibrosis and further used a rat cell line of HSC, HSC-T6, as a cell model, to investigate the effect of Hif-1α to HSC activation and also the effect of MAPK signaling to Hif-1α activity, thus providing new targets for preventing the progress of liver fibrosis.