Conclusively, it was shown in present study that Hif-1α was induced in liver tissues of Schistosomajaponicum infected mice, Hif-1α regulated the activation of hepatic stellate cells upon hypoxia stimulation and MAPK signaling mechanism was involved in regulation of Hif-1α regulated cascade, which provides us new targets to inhibit the development and progress of hepatic fibrosis. This evidence concerns the gene HIF1A and Hepatic fibrosis.