Given extravagant aging-related myocardial ‘aldehydic load’ was responsible for intolerance of the senescent heart to I/R insult, pharmacological ALDH2 activation provides an effective solution for ameliorating this aging-related unbalance, which providing a strong experimental proof for clinical application of ALDH2 agonist in patient with MI and other ALDH2-related diseases, especially for the elder. Here, ALDH2 is linked to myocardial infarction.