Indeed, accumulation of AP, one of the most abundant MG-derived AGEs [3], [4], has been found in the present study, either in differently aggressive and invasive PCa cell lines models, or in biological fluids of patients with differently aggressive and invasive PCa, where such an accumulation well matched the presence of a less functioning GLO1 enzyme as well as a significant condition of oxidative stress. The gene discussed is GLO1; the disease is posterior cortical atrophy.