RP Sahu et al also found that silencing ATM or Chk1 expression abrogated ATM (pSer-1981) and Chk1 (pSer-345) activations in curcumin-treated human pancreatic cancer cells and subsequently prevented the cells from undergoing G2/M cell cycle arrest [36]. The gene discussed is CHEK1; the disease is familial pancreatic carcinoma.