The mice transplanted with SIL-TAL1+ T-ALL cells (SIL-TAL1+ mice) had earlier disease onset (14±0 days) than those mice transplanted with SIL-TAL1− T-ALL cells (SIL-TAL1− mice) (28.9±13.4 days, Figure 3A, P<0.001). The gene discussed is TAL1; the disease is acute lymphoblastic leukemia.