TP53 and neoplasm: In addition, recent studies indicate that tumor susceptible mice (p53-/-) crossed with Sall2-deficient mice (Sall2 -/- or Sall2 -/+/p53 -/- mice) exhibited significantly accelerated tumorigenesis and mortality rate compared to Sall2 +/+/ p53-/- mice suggesting a synergy between p53 and SALL2 [58].