Furthermore, NRF2 reportedly regulates expression of the MDM2 gene that encodes a negative regulator of p53, and this study shows that lung cancer patients with homozygous SNP alleles (–617A/A) in the NRF2 gene and the 309T (WT) allele in the MDM2 gene had markedly better overall survival. This evidence concerns the gene NFE2L2 and lung cancer.