CRH and irritable bowel syndrome: Specifically, acute stressors and CRF injected into the brain or the periphery induces a rapid onset stimulation of colonic motor function in rodents, a response that is largely mediated by activating CRF1 receptors in both the brain and the colon and reproducing symptoms of irritable bowel syndrome (IBS) with diarrhea (IBS-D) [8], [9].