Other mammalian hepatocytes have been reported to accumulate high levels of EPA and DPA in cells phospholipid within 1–2 days from supplemented ALA [23], [38], [42], and cell lines from other tissues, such as human colon carcinoma (CaCo-2), had a significant increase in Fads2 enzyme activity at the end of a 3-day experiment [40]. This evidence concerns the gene FADS2 and colon carcinoma.