An active case finding among ambulatory PLWHA with good immunological status (CD4 count >200 cells/μL) showed that 8 of 10 PLWHA with no TB symptoms were prescribed IPT for more than 4 weeks before the bacteriological confirmation of their active TB status [10] and may potentially contribute to isoniazid resistance since a single drug was offered to active TB cases. This evidence concerns the gene CD4 and tuberculosis.