Nevertheless, the link between these mechanisms lies in the common genetic and signaling pathways, like Wnt, β-catenin, K-ras, p53, transforming growth factor TGF-β, tumor necrosis factor TNF-a, and the DNA mismatch repair (MMR) proteins, which are altered in sporadic colorectal cancer through specific mutations in these molecules [47]. The gene discussed is TP53; the disease is colorectal cancer.