CASP8 and neoplasm: GB treatment also resulted in PS translocation to the outer leaflet of the plasma membrane on B-lineage tumor cells (Nalm-6 and BJAB) and inflicted cytotoxicity, implicating the TNF-α → caspase-8 activation → caspase-3 activation → PARP-1 cleavage → DNA fragmentation signaling pathway that encompasses early-to-late biochemical events that are hallmarks of apoptosis.