Although mutations in the C. parasitica Prodh and P5Cdh genes did not appear to have an impact on the accumulation of hypovirus dsRNA, viral infection did cause profound phenotypic changes to the mutants: Δprodh/CHV1-EP713 had similar colony morphology as EP713, but Δp5cdh/CHV1-EP713 showed a distinct phenotype (Figure 6A). Here, ALDH4A1 is linked to viral infectious disease.