IGFBP5 and Familial prostate cancer: Figure 2B depicts strong down-regulatory effects of miR-211 mimic on mRNA levels of the newly identified putative RAB22A, SERINC3 and AP1S2 target genes in different cell lines and NHEMs, which became visible after 24 h and remained stable for up to 3 days. Effects on IGFBP5 (insulin-like growth factor binding protein 5) were generally less consistent in melanoma cells but significant in prostate cancer cells (PC3). Eleven additional potential targets have been analyzed by qPCR after mimic treatment (data not shown) and results are summarized in Table 1.