TGFBR2 and neoplasm: In this context, the initially described tumor-suppressive and anti-invasive properties of TRPM1 [28] have recently been shown to be executed by its intronic miR-211 (and not by TRPM1 itself) via down-regulation of the miR-211 direct and indirect targets TGFBR2, NFAT5, and IGF2R [11].