Therefore, we speculate that MITF is the key factor influencing melanoma cell behavior by directly driving transcription of its melanocyte-lineage specific target genes (MLANA, TYR, TRPM1 etc.)as well as by indirectly up-regulating the intronic miR-211, which in turn down-regulates a number of target genes that may altogether participate in modulating melanoma growth behavior. This evidence concerns the gene MITF and melanoma.