Increased expression levels of cleaved caspase 3, capase-cleaved product of cytokeratin 18 and p21WAF/Cip1 were found both in xenografted tumors of mice transplanted with ZM198,615 pretreated HCT-116 cells, receiving continued treatment from the day of implantation, and in xenografted tumors of mice transplanted with untreated HCT-116 cells, receiving treatment after tumor appearance. This evidence concerns the gene KRT18 and neoplasm.