Our results further supported by the recent study by Szymanska et al. [26], strongly suggest a remodelling of phospholipid species, which may result from a multi-factorial origin, including dietary factors, gut functional ecology, intestinal absorption, as well as Platelet-Activating Factor (PAF) metabolic pathways and phospholipase A2 activities [46], [47], which are modulated by obesity and insulin resistance [3], [48]. This evidence concerns the gene PCLAF and obesity due to melanocortin 4 receptor deficiency.