At the time of clinical admission or shortly after cooling, the concentration of circulating interleukin (IL)-1, IL-1, IL-1 receptor antagonist (IL-1Ra), IL-6, soluble IL-6 receptor (sIL-6R), IL-10, interferon (IFN), tumor necrosis factor (TNF), and/or soluble TNF receptors subtype I (sTNF-RI) and subtype II (sTNF-RII) have been shown to be elevated in some HS patients [7]–[10]. This evidence concerns the gene TNF and histiocytic sarcoma.