We evaluated the levels of the EDN/RB, HJURP, p60/CAF-1 and PDLI4 proteins by immunohistochemistry in six adult brain samples, four foetal brain samples and 96 high-grade glioma samples, including 64 glioblastomas (grade IV) and 32 grade III gliomas (24 AA and 8 AO). This evidence concerns the gene RNASE2 and central nervous system cancer.