Several epilepsy candidate genes are downstream targets of Rbfox proteins (FLNA, SLC1A3, DCX, GABRB3, GAD2, KCNQ2, SCN8A, SLC12A5, SV2B, SYN1) and their regulation of expression and splicing has been demonstrated [18], [19]. The gene discussed is SV2B; the disease is epilepsy.