Although a meta-analysis [44] indicated an association between BC risk and genotype for Pro198Leu (GPX1) in premenopausal women, a genome-wide association study (GWAs) approach failed to find any statistically significant associations for either rs1050450 (GPX1) or rs4880 (SOD2) [44], [45], [46]. The gene discussed is SOD2; the disease is breast cancer.