The human SePP gene (SEPP1) contains several functional polymorphisms, including rs3877899 (Ala234Thr) and rs7579 (a G/A base change in the 3′UTR of SEPP1 mRNA) which affect plasma and lymphocyte selenoprotein activity in vivo and the relative proportion of plasma SePP isoforms [21], [22]; in addition both SNPs have also been reported to be associated with colorectal and prostate cancer risk [23], [24], [25]. The gene discussed is SELENOP; the disease is Familial prostate cancer.