Among other extracellular matrix genes, upregulation of periostin, connective tissue growth factor (Ctgf) and WNT1 inducible signaling pathway protein 1 (Wisp1) were most interesting, since their involvement in triggering myocardial fibrosis and heart failure has been previously established [48]–[52]. The gene discussed is CCN4; the disease is Myocardial fibrosis.