For example, a k = 12 clique community, consisting of 14 downregulated miRNAs, is found in the downregulated miRNA-miRNA network, and at least four significant pathways derivative subpathways are co-regulated by this clique, including Pathways in cancer, Focal adhesion, and ErbB signaling, and the MAPK signaling pathway. This evidence concerns the gene EGFR and cancer.