We also observed a moderate association of AD for CHAT 2384G >A polymorphism (OR = 1.22, 95% CI = 1.00–1.49, P = 0.05), and an association of AD for LPL Ser447Ter polymorphism in the Northern-American population (OR = 0.56, 95% CI = 0.35–0.91, P = 0.02). This evidence concerns the gene LPL and Alzheimer disease.