HGF and adenocarcinoma: In a co-culture system, we detected a time-dependent increase in miR-21 expression in the HGF-1 fibroblasts when co-cultured with the adenocarcinoma cell line FLO-1 while KYSE-30 cells showed a time-dependent increase of miR-21 expression when co-cultured with HGF-1 fibroblasts.