ESR1 and endometrial cancer: As showed in Figs. 5A and 5B, human endometrial cancers (n = 24) with low expression of nuclear ERα (histoscore ≤45) were found to have significantly higher expression of both GPR30 and pFAK as compared to those (n = 25) with high ERα (histoscore >45) (p<0.0001) (Table 1).