Here we report, in agreement with our previous study [12], that the mechano-response of human AF cells to 1.0 Hz CTS differs between AF cells derived from non-degenerate and degenerate IVDs, with ADAMTS -4 gene expression decreased in non-degenerate AF cells and type I collagen gene expression decreased in degenerate AF cells. The gene discussed is ADAMTS4; the disease is atrial fibrillation.