FXYD1 and myocardial infarction: Consistent with the alternation of myocyte membrane excitability, western blot analysis revealed significant up-regulation of PLM at the protein level in cardiac tissue in OVX+MI rats compared to MI rats (n = 8, P<0.05, Fig. 3C), and this up-regulation was 1.5-fold greater in OVX+MI than in MI rats.