BCL2 and breast carcinoma: As shown in Fig. 5, ACCA decreased Bcl-2 protein level (1.8-, 2.4-, and 2.6-fold, respectively) whereas Bax protein expression were elevated (3.4-, 2.4, and 3.2-fold, respectively) in MCF-7, T47D and MDA- 231 breast cancer cells, respectively.