Our previous study showed that chrysanthemumindicum ethanolic extract (CIE) substantially suppressed the proliferation and invasiveness of a HCC cell line (MHCC97H), with a notable decrease in MMP-2 and MMP-9 expression and a simultaneous increase in TIMP-1 and TIMP-2 expression [30]. This evidence concerns the gene MMP2 and hepatocellular carcinoma.