EGF and asthma: While previous studies have demonstrated that bronchial epithelial cells from normal and asthmatic donors generate pro-inflammatory mediators ex vivo that can influence neutrophil functional responses [14], [17], [43], [45], this study provides the first evidence that an EGF-induced airway epithelium can upregulate neutrophil accumulation in relation to asthma severity in a PI(3)Kγ dependent fashion.