NLGN2 was detected exclusively in inhibitory synapses so far [4], [13], [14] and it is of particular interest, because mutations in human NLGN2 gene were implicated in schizophrenia [18], whereas manipulations of mouse NLGN2 levels resulted in characteristic behavioral phenotypes, including an increase in anxiety levels both in NLGN2-KO and NLGN2-overexpressing mice [19]–[21]. The gene discussed is NLGN2; the disease is Anxiety.